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Overview

HYPOTHESES:

1. Nutrients and non-nutrients can modulate other important pathways in eukaryotic systems that regulate stress response signaling.
 
2. Nutrients and non-nutrients that can positively modulate positively different stress response signaling may prove to be beneficial in management of diseases that can result from their dysregulation.
 
OBJECTIVES:
In our laboratory we evaluate the effect of nutrients and non-nutrients on stress response signaling pathways in eukaryotes.  Understanding mechanism of action of these bioactive compounds may have implications in development of therapeutic strategies for aging related pathologies, neurodegenerative diseases (Alzheimer’s disease and Parkinson’s disease) and metabolic diseases such as diabetes.
 
AIM-1: Evaluate the in vivo dose-dependent effect of nutrients and non-nutrients on modulation of IGF/PI3K, SKN-1, MAPK, HSP, UPR, HIF, Apoptosis and TGF-b signaling in transgenic C. elegans and D. melanogaster models. 
 
AIM-2: Evaluate the effect of nutrients and non-nutrients on attenuation of in vivo using C. elegans and D. melanogaster model for aging related pathologies, neurodegenerative and metabolic diseases.  
 
AIM-3: Mechanistic evaluation of nutrients and non-nutrients on attenuation of neurodegeneration induced by excitotoxicity and protein toxicity in cultured primary neuronal cells from chick embryo.
 
AIM-4: Effect of nutrients and non-nutrients on aggregation kinetics of Amyloid beta peptide aggregation using spectrometric techniques.
 
AIM-5: Structural and physiochemical characterization of potential bioactive compounds using advanced spectrometric analysis.